AOD 9604 5mg

AOD-9604 and lipid-metabolism research

AOD-9604 5mg is a synthetic 16-amino-acid peptide based on the C-terminal region of human growth hormone. Its structure combines hGH residues 177-191 with an N-terminal tyrosine, giving rise to the research notation Tyr-hGH(177-191).

Exploring a selected region of growth hormone

The development rationale was to investigate lipid-related actions associated with a selected GH region. This gives AOD-9604 a different research focus from GHRH analogues, which stimulate pituitary growth hormone release.

Experiments in obese mice measured changes in body weight, fat mass and lipid metabolism. Studies using beta-3-adrenoceptor knockout mice helped examine the role of that signalling pathway. These models allow researchers to explore the relationship between peptide structure and metabolic responses under controlled conditions.

Translation into human studies

AOD9604 also progressed into clinical obesity research. Although early observations encouraged further development, the larger study did not establish statistically significant weight loss over placebo at the reported endpoints. Its results define a limitation of the clinical evidence while leaving the mechanistic findings relevant to laboratory research.

The clearest scientific context for the 5mg product is therefore GH-fragment biology and experimental lipid metabolism, with human weight-management outcomes considered separately.

Also known as / branded as

• AOD-9604
• AOD9604
• Tyr-hGH(177-191)